Diagnosis of drug causality in non-immediate drug hypersensitivity in children
نویسندگان
چکیده
منابع مشابه
Non-steroidal anti-inflammatory drug hypersensitivity in children.
INTRODUCTION There are rather few publications about hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAID) in the paediatric age. In this study, we aimed to assess the frequency of confirmed NSAID hypersensitivity in children with a previous reported reaction to NSAID in order to investigate the role of the drug provocation test (DPT) in the diagnostic workup and to explor...
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Background and Objective: Type I drug hypersensitivity reactions causes immune responses that could endanger life. Therefore this study was designed with the aim of evaluation and register reactions that caused by chemotherapy in hospitalized children in Rasoul Akram Hospital in 2015. Methods: This is a descriptive, cross sectional study. All statistical calculation was performed using the v...
متن کاملDrug hypersensitivity in children in Brazil
Results Ninety patients were evaluated, 54 male, with a median age of 6 years. Personal history of atopy was reported in 65 and previous DHR in 9. Cutaneous manifestations were observed in 86 – urticaria and/or angioedema in 71 and macular or maculopapular exanthema in 15. Other symptoms reported were: respiratory (25), gastrointestinal (8), cardiovascular (5). The interval between dose and rea...
متن کاملThe "nocebo effect" in drug hypersensitivity diagnosis
Background Placebo-controlled oral drug provocation tests (DPTs) are an important step in drug hypersensitivity diagnosis. Administration of placebo (an inert sostance not detectable from drug) is recommended to avoid psychological influences on the interpretation of DPT results, however actually little is known about how to deal a reaction to placebo and how to go further with the diagnostic p...
متن کاملIn Vitro Diagnosis of Immediate Drug Hypersensitivity Anno 2017: Potentials and Limitations
BACKGROUND For most physicians, quantification of drug-specific immunoglobulin E (drug-sIgE) antibodies constitutes the primary in vitro measure to document immediate drug hypersensitivity reactions (IDHR). Unfortunately, this is often insufficient to correctly identify patients with IgE-mediated IDHR and impossible for non-IgE-mediated IDHR that result from alternative routes of basophil and m...
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ژورنال
عنوان ژورنال: Expert Review of Clinical Pharmacology
سال: 2018
ISSN: 1751-2433,1751-2441
DOI: 10.1080/17512433.2018.1494570